invitroTKstats - In Vitro Toxicokinetic Data Processing and Analysis Pipeline
A set of tools for processing and analyzing in vitro
toxicokinetic measurements in a standardized and reproducible
pipeline. The package was developed to perform frequentist and
Bayesian estimation on a variety of in vitro toxicokinetic
measurements including -- but not limited to -- chemical
fraction unbound in the presence of plasma (f_up), intrinsic
hepatic clearance (Clint, uL/min/million hepatocytes), and
membrane permeability for oral absorption (Caco2). The methods
provided by the package were described in Wambaugh et al.
(2019) <doi:10.1093/toxsci/kfz205>.
