Apparent Membrane Permeability (Caco-2)8 months ago
Introduction | Suggested packages for use with this vignette | Load Data | Level 1 processing | Level 2 processing | Level 3 processing | Best Practices: Food for thought | References
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Intrinsic Hepatic Clearance (Cl~int~)8 months ago
Introduction | Suggested packages for use with this vignette | Load Data | Level 1 processing | Level 2 processing | Level 3 processing | Level 4 processing | Best Practices: Food for thought | Appendix | L4 Bayesian Modeling Information | Measurement Model | Estimation of Blanks | Estimation of Calibration Curve | Clearance Model | Estimation of Metabolic Clearance | Estimation of Abiotic Clearance | Post-MCMC Estimates | JAGS to L4 Equation Notation Tables | References
Fraction Unbound in Plasma - Rapid Equilibrium Dialysis (f~up~ RED)8 months ago
Introduction | Suggested packages for use with this vignette | Load Data | Level 1 processing | Level 2 processing | Level 3 processing | Level 4 processing | Best Practices: Food for thought | Appendix | L4 Bayesian Modeling Information | Measurement Model | Estimation for Blanks with No Plasma | Estimation for Blanks with Plasma | Estimation for Initial Time (T0) | Estimation for the Calibration Curve | Estimation for the RED Plasma Protein Binding Assay | Concentrations for Replicates | Estimation for PBS | Estimation for Plasma | Post-MCMC Estimates | Fraction of Chemical Unbound in Plasma (Bayesian Estimates) | Fraction Unbound in Plasma (Empirical Point Estimate) | JAGS to L4 Equation Notation Tables | References
Fraction Unbound in Plasma - Ultracentrifugation (f~up~ UC)8 months ago
Introduction | Suggested packages for use with this vignette | Load Data | Level 1 processing | Level 2 processing | Level 3 processing | Level 4 processing | Best Practices: Food for thought | Appendix | L4 Bayesian Modeling Information | Measurement Model | Estimation of Response Observations | Binding Model | Post-MCMC Estimates | Fraction of Chemical Stability | Fraction of Chemical Unbound in Plasma (Bayesian Estimates) | Fraction Unbound in Plasma (Empirical Point Estimate) | JAGS to L4 Equation Notation Tables | References
Appendix1 years ago
Introduction | Data Notation | Function Notation
Data Guide Creation and Level-0 Data Compilation1 years ago
Overview | Suggested packages for use with this vignette | Raw Data File Exploration | Data Catalog | Chemical ID Map | Level-0 (L0) Data Compilation | Best Practices for Data Processing | References
Plotting Functions1 years ago
Introduction | Set Up | plot_clint.R | plot_fup_uc.R | References